Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet

The brain renin–angiotensin system (RAS) has been recently involved in the homeostatic regulation of energy. Our goal was to analyse influence a diet rich saturated fatty acids (butter) against one enriched monounsaturated (olive oil) on hypothalamic RAS, and their relationship with metabolism acids. Increases body weight visceral fat, together an increase aminopeptidase A expression reductions AngII AngIV were observed hypothalamus animals fed butter diet. In this group, marked reduction genes related lipid (LPL, CD36, CPT-1) liver muscle. No changes found terms weight, total fat hepatic acid olive oil expressions LPL CD36 reduced muscles, although decrease lower than At same time, fasting levels leptin reduced, no decreases noted AngII, AngIII. These results support that type dietary is able modify profile RAS energy balance, metabolism.